104學年度第二學期專題討論統計學術演講公告
統計碩士學位學程將於104年3月1日(星期二)舉辦統計學術演講，邀請到國家衛生研究院群體健康科學研究所鄒小蕙副研究員蒞臨演講，
講題：Combining Evidence of Regional Treatment Effects and Assessing Consistency across Regions under DREM in MRCTs
講員：鄒小蕙 副研究員 國家衛生研究院群體健康科學研究所
時間：2016年3月1日星期二 下午 3：30 ~ 5：30
地點：臺灣大學博雅教學館408教室
摘要：
In recent years, developing pharmaceutical products via a multiregional clinical trial (MRCT) has become standard. Traditionally, the treatment effect was assumed to have a fixed positive value over all regions in an MRCT. However, regional heterogeneity caused by differences in race, genetic fingerprints, diet, environment, culture, medical practice, and disease etiology among regions in an MRCT has been observed and may have an impact upon a medicine’s treatment effect. In this presentation, we will discuss the issue of combining evidence of regional treatment effects in multiregional clinical trials. We will introduce a discrete random-effects model (DREM) to account for heterogeneous treatment effects across regions for the design and evaluation of MRCTs. We will illustrate determination of the overall sample size and address the issues of consistency across regions under DREM in an MRCT.
歡迎對於此議題有興趣的師生同仁參加。現場坐位有限，敬請及早報到入場。
聯絡人：張仲凱
聯絡方式：E-mail：ntustat@ntu.edu.tw
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